Lupus or systemic lupus erythematosus (SLE) is an inflammatory disease (inflammation), chronic attacks various parts of the body, especially skin, joints, blood, and kidneys. “

Normally, the body’s immune system produces proteins called antibodies. The function of antibodies to fortify the body against viruses, and bacteria (called antigens). If the function fortify yourself (autoimmunity) is disturbed, then the immune system loses the ability to distinguish between antigen with tissue / cell body itself. This is what happens in people with lupus.

Furthermore, the immune system to form autoantibody, the term for the type of antibodies that actually attack the body’s own tissues. Autoantibody is then used to form an immune complex systems, ie systems that lead to inflammation, injury, or infection of the tissues and cells, and cause pain to the sufferer. “In short, when compared with the disease of HIV / AIDS, which lead to decreased immunity, then in patients with lupus, the immune system would become wild and attack ourselves,” said dr. Cecilia.

Unfortunately, many people think of lupus as a rare disease. The truth, the number of patients increasingly lot. Moreover, according to data from the Lupus Foundation of Indonesia, in recent years continued to increase the number of Odapus (people with lupus). Increase about 17% each year.

If not detected early, the disease is the same fraction of ti dangers of cancer, coronary heart disease, and AIDS. The difficulty, the cause of the disease is not known. So, how to prevent it was not yet known. According to dr. Cecilia, until now the experts are still figuring out the cause of the emergence of lupus.

Although women who have a family history of lupus disease are at higher risk experiencing the same disease, lupus in fact can not always be said to be a hereditary disease. Until now, the prevalence of lupus patients due to genetic factors only reached 10%. Factors that very act is suspected environmental conditions, such as sun exposure, stress, effects of some drugs, and viruses.

Although it was thought the disease is triggered because of the wrong lifestyle, including eating unhealthy foods, dr. Cecilia admitted less convinced of the truth. Aya was agreed. “Before I was diagnosed, I was pretty healthy lifestyle, really. In fact, I rarely eat junk food, “he said.

So, why are more women sufferers? According to dr. Cecilia, lupus disease is also associated with the dominant hormone estrogen in women. Similar to stress, excessive estrogen production also affect the immune cells of the body.

Lupus is a disease that attacks the immune system changes individuals, which until now unknown cause. This disease arise due to dysfunction of the immune system. In one’s body contained antibodies that attack the source function disease to be included in the body. Uniquely, this lupus antibodies formed in the body appears excessive. As a result, the antibodies actually attack the cells of a healthy organ tissue.

The disorder is called autoimmunity.

This excess antibodies, can go into the entire network with two
ways:.

• First, antibodies can directly attack this strange body tissue,

as in red blood cells that cause the cells will be destroyed.
This is what lead to the sufferer or red blood cell deficiency
anemia.

• Second, antibodies can be joined with antigens (substances stimulating formation

determine antibody), forming a bond called a complex imun.Gabungan
antibody and antigen flow with blood, until caught in development
capillary blood vessels will cause inflammation.

Under normal circumstances, this complex will be limited by inflammatory cells
(Phagocytes) However, in abnormal circumstances, this complex can not
properly restricted. In fact, inflammatory cells had increased a lot while
secrete enzymes that cause inflammation around the complex.

As a result, the inflammatory process will be prolonged and will damage
organs and interfere with its function. Furthermore, it will be seen
as symptoms of the disease. If this happens, then in the long term
organ function will be disrupted.

Generally, people with lupus experience symptoms such as. Easy skin
scorched by the sun and the incidence of digestive disorders.
Symptoms generally sufferers often feel weak, fatigue
excessive, fever and sore. This phenomenon is mainly observed in
active period, whereas during remission (inactive) disappeared.

A new molecular tool could become a therapeutic option for acute myeloid leukemia.

According to a study published in the latest issue of Cell Stem Cell, preclinical studies conducted by a team from Children Cancer Institute Australia have demonstrated that CD123 molecule is over expressed in leukemia stem cells, whereas its expression in healthy cells is normal.

This molecule is part of the interleukin-3 receptor, a protein that interacts with a growth factor linked to survival and cell proliferation.

The creation of a monoclonal antibody that binds to CD 123 for attempting to interfere selectively in the survival of leukemia stem cells is the main innovation offered by the work coordinated by Richard Lock.

When tumor stem cells were transplanted into mice treated with the antibody, known as 7G3, cytokine signaling in cancer cells was blocked.

In addition, 7G3 inhibited the migration of leukemia stem cells in the marrow and activated the innate immune system of animals to destroy diseased cells.