A study finds that the risks of transplant failure and death will increase if the organ comes from a dead man
According publishes the Journal of the American Society of Nephrology “, Canadian researchers have found that recipients of female kidneys, which donated organ came from a dead man face greater risk of failure during the first year after transplantation
The authors say the risk is short term, however. It could be caused by proteins of male donor cells. Their study found that the risk disappears after ten years.
The researchers analyzed data on 117,877 adults whose kidney transplants were performed in the United States between 1990 and 2004. The kidneys were from deceased donors. Within a year, the failure of the transplant had occurred in 6878 and 16,135 people had died. Among the 97,906 people who were followed for up to ten years after transplantation, there were 35,084 and 22,566 transplant failure deaths.
Year risk of graft failure
In comparison with other combinations of gender, recipients of kidneys from men had a 12% higher risk of failure and an increased risk of death similar one years after transplantation. They had no greater risk of failure or death after decade.
The researchers, from the University of Toronto and the University of British Columbia, noted that the HY antigens derived from the male chromosome that are not present in women could cause adverse immune responses in women who receive kidneys from men who have died.
They recommended that “future research should examine potential mechanisms underlying the HY effect to better understand the specific role of minor histocompatibility antigens in determining the outcome of allergenic transplants.